Author Archives: GG


Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps. André C, Martiel I, Wolff P, Landolfo M, Lorber B, Silva da Veiga C, Dejaegere A, Dumas P, Guichard G, Oliéric V, Wagner J, Burnouf DY. … Continue reading


Hybrid Cell-Penetrating Foldamer with Superior Intracellular Delivery Properties and Serum Stability. Douat C, Bornerie M, Antunes S, Guichard G, Kichler A. Bioconjug. Chem. 2019, 30 (4), 1133-1139. link


Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo. Frémaux J, Venin C, Mauran L, Zimmer RH, Guichard G, Goudreau SR. Nat. Commun. 2019, 10 (1), 924. link


Design and Structure Determination of a Composite Zinc Finger Containing a Nonpeptide Foldamer Helical Domain. Lombardo CM, Kumar M V V, Douat C, Rosu F, Mergny JL, Salgado GF, Guichard G. J. Am. Chem. Soc. 2019, 141 (6), 2516-2525. link


1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD). Baudin A, Guichard A, Collie GW, Rousseau S, Chaignepain S, Hocquellet A, Berbon M, Loquet A, Mackereth … Continue reading

Bordeaux 2018 Symposium on Foldamers

Not to be missed! IECB will host the Bordeaux 2018 Symposium on Foldamers on September 24-26, 2018. Registration and Abstract submission Deadline June 15, 2018 !


Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes. Chekkat N, Lombardo CM, Seguin C, Lechner MC, Dufour F, Nominé Y, De Giorgi M, Frisch B, Micheau O, Guichard G, Altschuh D, Fournel … Continue reading


Postelongation Strategy for the Introduction of Guanidinium Units in the Main Chain of Helical Oligourea Foldamers. K. Pulka-Ziach, S. Antunes, C. Perdriau, B. Kauffmann, M. Pasco, C. Douat, G. Guichard. J. Org. Chem. 2018, 83 (5), 2530-2541. link

Spotlight on our JACS Publication

Our latest publication on « Metal-Free Catalysts: Peptide-Inspired Foldamers for Chiral H-Bond Donation » has been highlighted by the Editors of JACS.

Congratulations to Léonie!

Léonie has been awarded the Oral Communication prize at the Journée Grand Sud-Ouest 2017 from the French Chemical Society (SCF) held in Toulouse, France.