Author Archives: GG


Foldamers in Medicinal Chemistry. M. Pasco, C. Dolain, G. Guichard, in  Comprehensive Supramolecular Chemistry II, ed Atwood JL (Elsevier, Oxford), Vol 5, pp 89–125.

Our Chapter in the book Comprehensive Supramolecular Chemistry II

Our chapter entitled Foldamers in Medicinal Chemistry has just been released in the Reference work Comprehensive Supramolecular Chemistry II.

Congratulations to Laura !

Laura has been awarded the Best Poster prize at the 53rd International Conference on Medicinal Chemistry RICT 2017 in Toulouse, France.


Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers. Antunes S, Corre JP, Mikaty G, Douat C, Goossens PL, Guichard G. Bioorg Med Chem. 2017, 25(16), 4245-4252. link

Congratulations to Diane !

Diane has been awarded the Oral Communication prize at the XLII edition of the « Attilio Corbella » International Summer School on Organic Synthesis (ISOS 2017) held in Gargnano, Italy.

Molecular Recognition within the Cavity of a Foldamer Helix Bundle

Our latest publication on molecular recognition within the cavity of a foldamer helix bundle has been published and highlighted on the cover of the Journal of the American Chemical Society.   About the Cover: Towards the development of functional water-soluble … Continue reading


Proline-rich antimicrobial peptides targeting protein synthesis. Michael Graf, Mario Mardirossian, Fabian Nguyen, Carolin A. Seefeldt, Gilles Guichard, Marco Scocchi, Axel C. Innis and Daniel N. Wilson. Nat. Prod. Rep. 2017, doi: 10.1039/c7np00020k. link


Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions. Gavin W. Collie, Remy Bailly, Karolina Pulka-Ziach, Caterina M. Lombardo, Laura Mauran, Nada Taib-Maamar, Jean Dessolin, Cameron D. Mackereth, and Gilles Guichard. J. … Continue reading


N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. Florent Dufour, Thibault Rattier, Sarah Shirley, Gaelle Picarda, Andrei Alexandru Constantinescu, Aymeric Morlé, Al Batoul Zakaria, Guillaume Marcion, Sebastien Causse, Eva Szegezdi, Dirk Michael Zajonc, Renaud Seigneuric, Gilles Guichard, Tijani … Continue reading


Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling. Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel. Cell Death and Disease 2017, 8, e2601; doi:10.1038/cddis.2017.22 link