Our research in peptidomimetic chemistry

Our research in

Peptidomimetic chemistry

Functions fulfilled by proteins depend to a large extent on the ability of the intrinsically flexible polypeptide chain to fold correctly into well-ordered and compact tertiary structures and eventually to (self-)assemble. Multiple approaches, at the interface between biology, synthetic organic and polymer chemistries are currently being developed to elaborate synthetic systems with protein-like structures and functions.

 

By using peptidomimetic chemistry, the general aims of our research are (i) to understand how to program molecules with the necessary information for self-ordering into complex and functional architectures, (ii) to create folded systems mimicking protein secondary structure elements (e.g. helices), (iii) to study interactions with biomolecules and to develop biomedical applications.

Foldamer chemistry

 

Synthesis of folded and self-assembled architectures mimicking proteins

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foldamer chemistry

Chemical biology and medicinal chemistry

 

 

From protein surface recognition to peptide therapeutics

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chemical biology medicinal chemistry

Molecular Recognition and Catalysis

 

Synthesis of folded and self-assembled architectures mimicking proteins

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molecular recognition