Covers & Papers






Nature-inspired synthetic oligourea foldamer channels allow water transport with high salt rejection


Structural Effect of Organic Catalytic Pairs Based on Chiral Amino(thio)ureas and Phosphazene Bases for the Isoselective Ring-Opening Polymerization of Racemic Lactide.


Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.


Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers.


PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase.


In Situ Generated DBU⋅HF Acts as a Fluorinating Agent in a Hexafluoroisobutylation Tandem Reaction: An Effective Route to 5,5,5,5’,5’,5’-Hexafluoroleucine.


Cell-free synthesis of amyloid fibrils with infectious properties and amenable to sub-milligram magic-angle spinning NMR analysis.


Block Copolymer Synthesis by a Sequential Addition Strategy from the Organocatalytic Group Transfer Polymerization of Methyl Methacrylate to the Ring-Opening Polymerization of Lactide


Reaching High Stereoselectivity and Activity in Organocatalyzed Ring-Opening Polymerization of Racemic Lactide by the Combined Use of a Chiral (Thio)Urea and a N-Heterocyclic Carbene


Adaptive Binding of Alkyl Glycosides by Nonpeptidic Helix Bundles in Water: Toward Artificial Glycolipid Binding Proteins


Insight into Substrate Recognition by Urea-Based Helical Foldamer Catalysts Using a DFT Global Optimization Approach


Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction


Design of oligourea-Based Foldamers with Antibacterial and Antifungal Activities


Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp


Crystal structures capture multiple stoichiometric states of an aqueous self-assembling oligourea foldamer


Urea based foldamers


A chiral thiourea and a phosphazene for fast and stereoselective organocatalytic ring-opening-polymerization of racemic lactide

M.S. Zaky, A. L. Wirotius, O. Coulembier, G. Guichard, D. Taton.

Chem. Commun. 2021, 57, 3777-3780.


Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity

J. MbiandaM. BakailC. AndréG. MoalM. E. PerrinG. PinnaR. GueroisF. BecherP. LegrandS. TraoréC. DouatG. GuichardF. Ochsenbein.

Science Advances 2021, 7 (12), doi: 10.1126/sciadv.abd9153



Delivery of siRNA by tailored cell-penetrating urea-based foldamers

M. BornerieA. Brion, G. GuichardA. KichlerC. Douat.

Chem. Commun. 2021, 57(12), 1458-1461.



Structural Basis for α-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers

L. CussolL. Mauran-AmbrosinoJ. BurattoA. Y. BelorusovaM. NeuvilleJ. OszS. FribourgJ. FremauxC. DolainS. R. GoudreauN. RochelG. Guichard.

Angew. Chem. Int. Ed. 2021, 60 (5), 2296-2303.


Formation and Modulation of Nanotubular Assemblies of Oligourea Foldamers in Aqueous Conditions using Alcohol Additives.

Yoo SH, Collie GW, Mauran L, Guichard G.

ChemPlusChem 2020, 85 (10), 2243-2250.


Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome.

RSC Chem. Biol., 2020,1, 137-147.


Characterization of the DNA and Membrane Interactions of a Bioreducible Cell-Penetrating Foldamer in its Monomeric and Dimeric Form.

Aisenbrey C, Douat C, Kichler A, Guichard G, Bechinger B.
J Phys Chem B. 2020, 124 (22), 4476-4486.


Pasco, M., Dolain, C., and Guichard, G. 2019,  In Supramolecular Chemistry in Water (Kubik, S., ed) pp. 337-374, Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim, Germany


Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking.
Fremaux J, Venin C, Mauran L, Zimmer R, Koensgen F, Rognan D, Bitsi S, Lucey MA, Jones B, Tomas A, Guichard G, Goudreau SR.
Chem Sci. 2019, 10 (42), 9872-9879.


Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps.
André C, Martiel I, Wolff P, Landolfo M, Lorber B, Silva da Veiga C, Dejaegere A, Dumas P, Guichard G, Oliéric V, Wagner J, Burnouf DY.
ACS Infect. Dis. 20195 (6), 1022-1034.



Hybrid Cell-Penetrating Foldamer with Superior Intracellular Delivery Properties and Serum Stability.

Douat C, Bornerie M, Antunes S, Guichard G, Kichler A.

Bioconjug. Chem. 2019, 30(4), 1133-1139.


Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo.
Frémaux J, Venin C, Mauran L, Zimmer RH, Guichard G, Goudreau SR.
Nat. Commun. 2019, 10 (1), 924.


Design and Structure Determination of a Composite Zinc Finger Containing a Nonpeptide Foldamer Helical Domain.
Lombardo CM, Kumar M V V, Douat C, Rosu F, Mergny JL, Salgado GF, Guichard G.
J. Am. Chem. Soc. 2019, 141 (6), 2516-2525.



1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD).
Baudin A, Guichard A, Collie GW, Rousseau S, Chaignepain S, Hocquellet A, Berbon M, Loquet A, Mackereth C, Guichard G, Odaert B.
Biomol. NMR Assign. 201812(2), 309-314.



Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes.

Chekkat N, Lombardo CM, Seguin C, Lechner MC, Dufour F, Nominé Y, De Giorgi M, Frisch B, Micheau O, Guichard G, Altschuh D, Fournel S.

Oncotarget20189 (21), 15566-15578.


Post-elongation Strategy for the Introduction of Guanidinium Units in the Main Chain of Helical Oligourea Foldamers.
K. Pulka-Ziach, S. Antunes, C. Perdriau, B. Kauffmann, M. Pasco, C. Douat, G. Guichard.
J. Org. Chem. 201883 (5), 2530-2541.



Synthesis and structural characterization of alkyne-functionalized N-heterocyclic carbene complexes of ruthenium, palladium and rhodium.

E. Chardon, G. Dahm, G. Guichard, S. Bellemin-Laponnaz

Inorg. Chim. Acta 2017, 467 (Supplement C), 33-38.



Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C-C Bond-Forming Reactions.

Bécart D, Diemer V, Salaün A, Oiarbide M, Nelli YR, Kauffmann B, Fischer L, Palomo C, Guichard G.

J. Am. Chem. Soc. 2017, 139(36), 12524-12532.



Foldamers in Medicinal Chemistry.

M. Pasco, C. Dolain, G. Guichard, in  Comprehensive Supramolecular Chemistry II, ed Atwood JL (Elsevier, Oxford), Vol 5, pp 89–125.




Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers.

Antunes S, Corre JP, Mikaty G, Douat C, Goossens PL, Guichard G.

Bioorg Med Chem. 2017, 25(16), 4245-4252.



Proline-rich antimicrobial peptides targeting protein synthesis.

Nat. Prod. Rep. 2017, doi: 10.1039/c7np00020k.



Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions.

Gavin W. Collie, Remy Bailly, Karolina Pulka-Ziach, Caterina M. Lombardo, Laura Mauran, Nada Taib-Maamar, Jean Dessolin, Cameron D. Mackereth, and Gilles Guichard.

J. Am. Chem. Soc. 2017139, 6128–6137.



N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Florent Dufour, Thibault Rattier, Sarah Shirley, Gaelle Picarda, Andrei Alexandru Constantinescu, Aymeric Morlé, Al Batoul Zakaria, Guillaume Marcion, Sebastien Causse, Eva Szegezdi, Dirk Michael Zajonc, Renaud Seigneuric, Gilles Guichard, Tijani Gharbi, Fabien Picaud, Guillaume Herlem, Carmen Garrido, Pascal Schneider, Chris Alan Benedict, and Olivier Micheau.

Cell Death Differ. 2017, 24, 500–510.



Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.

Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel.

Cell Death and Disease 2017, 8, e2601; doi:10.1038/cddis.2017.22



TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

Florent Dufour, Thibault Rattier, Andrei Alexandru Constantinescu, Luciana Zischler, Aymeric Morlé, Hazem Ben Mabrouk, Etienne Humblin, Guillaume Jacquemin, Eva Szegezdi, Fabien Delacote, Naziha Marrakchi, Gilles Guichard, Catherine Pellat-Deceunynck, Pierre Vacher, Patrick Legembre, Carmen Garrido, Olivier Micheau.

Oncotarget 2017, 8, 9974-9985.



Native ESI Mass Spectrometry Can Help to Avoid Wrong Interpretations from Isothermal Titration Calorimetry in Difficult Situations.

Philippe Wolff, Cyrielle Da Veiga, Eric Ennifar, Guillaume Bec, Gilles Guichard, Dominique Burnouf, Philippe Dumas.

J. Am. Soc. Mass Spectrom. 2017, 28, 347-357.



Anion Recognition by Aliphatic Helical Oligoureas.
Vincent Diemer, Lucile Fischer, Brice Kauffmann, and Gilles Guichard.
Chem. Eur. J. 2016, 22, 15684-15692.



Proteolytically Stable Foldamer Mimics of Host-Defense Peptides with Protective Activities in a Murine Model of Bacterial Infection.

Emilie Teyssières, Jean-Philippe Corre, Stéphanie Antunes, Catherine Rougeot, Christophe Dugave, Grégory Jouvion, Paul Claudon, Guillain Mikaty, Céline Douat, Pierre L. Goossens, and Gilles Guichard.

J. Med. Chem. 2016, 59, 8221-8232.



Anatomy of an Oligourea Six-Helix Bundle.

Caterina M. Lombardo, Gavin W. Collie, Karolina Pulka-Ziach, Frederic Rosu, Valerie Gabelica, Cameron D. Mackereth, and Gilles Guichard.

J. Am. Chem. Soc. 2016, 138, 10522-10530.



N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy.

Neila Chekkat, Georges Dahm, Edith Chardon, May Wantz, Justine Sitz, Marion Decossas, Olivier Lambert, Benoit Frisch, Riccardo Rubbiani, Gilles Gasser, Gilles Guichard, Sylvie Fournel, and Stéphane Bellemin-Laponnaz.

Bioconjug. Chem. 2016, 27, 1942-1948.



The meso Helix: Symmetry and Symmetry-Breaking in Dynamic Oligourea Foldamers with Reversible Hydrogen-Bond Polarity.

Romina Wechsel, James Raftery, Dominique Cavagnat, Gilles Guichard, and Jonathan Clayden.

Angew. Chem. Int. Ed. 2016, 55, 9657-9661.



Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels.

Julien Beyrath, Neila Chekkat, Cristian R. Smulski, Caterina M. Lombardo, Marie-Charlotte Lechner, Cendrine Seguin, Marion Decossas, Maria Vittoria Spanedda, Benoît Frisch, Gilles Guichard and Sylvie Fournel.

Oncotarget 2016, DOI: 10.18632/oncotarget.10508.



Solid-Phase Synthesis of Hybrid Urea Oligomers Containing Conservative Thiourea Mutations.
Stéphanie Antunes, Céline Douat and Gilles Guichard.
Eur. J. Org. Chem. 2016, 12, 2131-2138.



Surfactant-facilitated crystallisation of water-soluble foldamers.
G. W. Collie, K. Pulka-Ziach and G. Guichard.
Chem. Sci. 2016, 7, 3377-3383.



Post-functionalization of platinum-NHC complexes by oxime ligation for ligand targeted therapy.
Etienne Borre, Georges Dahm, Gilles Guichard and Stephane Bellemin-Laponnaz.
New J. Chem. 2016, 40, 3164-3171.



In situ iodination and X-ray crystal structure of a foldamer helix bundle.
Gavin W. Collie, Karolina Pulka-Ziach, and Gilles Guichard.
Chem. Commun. 2016, 52, 1202-1205.

From themed collection Foldamers guest edited by Samuel Gellman and Ivan Huc.



Stabilization of an α-helix by short adjacent accessory foldamers.
Laura Mauran, Brice Kauffmann, Benoit Odaert, and Gilles Guichard.
C. R. Chimie 2016, 19, 123-131.

This article belongs to a special issue Emerging Chemistry in France Edited By Ivan Huc, Jean-François Lutz and Christian Serre.



Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation.
Gavin W. Collie, Karolina Pulka-Ziach, Caterina M. Lombardo, Juliette Frémaux, Frédéric Rosu, Marion Decossas, Laura Mauran, Olivier Lambert, Valérie Gabelica, Cameron D. Mackereth and Gilles Guichard.
Nature Chemistry 2015, 7, 871-878.



A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA.
Céline Douat, Christopher Aisenbrey, Stéphanie Antunes, Marion Decossas, Olivier Lambert, Burkhard Bechinger, Antoine Kichler, and Gilles Guichard.
Angew. Chem. Int. Ed. 2015, 54, 11133-11137.



α-Peptide–Oligourea Chimeras: Stabilization of Short α-Helices by Non-Peptide Helical Foldamers.
Juliette Fremaux, Laura Mauran, Karolina Pulka-Ziach, Brice Kauffmann, Benoit Odaert, and Gilles Guichard.
Angew. Chem. Int. Ed. 2015, 54, 9816-9820.



The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.
A. Carolin Seefeldt, Fabian Nguyen, Stephanie Antunes, Natacha Perebaskine, Michael Graf, Stefan Arenz, K. Kishore Inampudi, Celine Douat, Gilles Guichard, Daniel N. Wilson, and C. Axel Innis.
Nat. Struct. Mol. Biol. 2015, 22, 470-475.



A Chemoselective and Modular Post-Synthetic Multi-Functionalization of NHC–Platinum Complexes
Georges Dahm, Etienne Borré, Gilles Guichard and Stéphane Bellemin-Laponnaz
Eur. J. Inorg. Chem. 2015,10, 1665–1668.



Isosteric Substitutions of Urea to Thiourea and Selenourea in Aliphatic Oligourea Foldamers: Site Specific Perturbation of the Helix Geometry.
Yella Reddy Nelli, Stéphanie Antunes, Arnaud Salaün, Emmanuelle Thinon, Stéphane Massip, Brice Kauffmann, céline Douat and Gilles Guichard.
Chem. Eur. J. 2015, 21, 2870–2880.



Thioether Analogues of Disulfide-bridged Cyclic Peptides Targeting Death Receptor 5 : Conformational Analysis, Dimerization and Consequences for Receptor Activation.
Karolina Pulka-Ziach, Valeria Pavet, Neila Chekkat, Karine Estieu-Gionnet, Roman Rohac, Marie-Charlotte Lechner, Cristian Smulski,  Gabrielle Zeder-Lutz, Daniele Altschuh, Hinrich Gronemeyer, Sylvie Fournel, Benoit Odaert and Gilles Guichard.
ChemBioChem. 2015, 16, 293–301.



Inducing achiral aliphatic oligoureas to fold into helical conformations.
Wechsel R, Maury J, Fremaux J, France SP, Guichard G, Clayden J.
Chem. Commun. 2014, 15006-15009.



Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
Philippe Wolff, Ismail Amal, Vincent Olieric, Olivier Chaloin, Gudrun Gygli, Eric Ennifar, Bernard Lorber, Gilles Guichard, Jérôme E Wagner, Annick Dejaegere, and Dominique Y Burnouf
J. Med. Chem. 2014, 57, 7565-7576.



Synthesis and Folding Propensity of Aliphatic Oligoureas Containing Repeats of Proline-type Units
Juliette Fremaux, Brice Kauffmann, Gilles Guichard
J. Org. Chem. 2014 79, 5494–5502.



Genes of the N-Methylglutamate Pathway Are Essential for Growth of Methylobacterium extorquens DM4 with Monomethylamine
Christelle Gruffaz,Emilie E. L. Muller, Yousra Louhichi-Jelail, Yella R. Nelli, Gilles Guichard, Françoise Bringel
Appl. Environ. Microbiol. 2014, 80, 3541-3550.



Structural characterization of short hybrid urea/carbamate (U/C) foldamers: A case of partial helix unwinding
Yella Reddy Nelli,  Lucile Fischer, Gavin W. Collie, Brice Kauffmann, Gilles Guichard
Biopolymers (Pept Sci) 2013 100, 687-97.



Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers
Juliette Fremaux,Christel Dolain,Brice Kauffmann,Jonathan Clayden and Gilles Guichard
Chem. Commun. 2013, 49, 7415-17.


Exploring Nitrogen Ligand Diversity in trans-N-Heterocyclic Carbene–Amine Platinum Complexes : Synthesis, Characterization, and Application to Fluorescence
Edith Chardon, Georges Dahm, Gilles Guichard and Stéphane Bellemin-Laponnaz
Chem. Asian J. 2013. 8, 1232–1242.



Helix-Forming Propensity of Aliphatic Urea Oligomers Incorporating Noncanonical Residue Substitution Patterns
Nagendar Pendem, Céline Douat, Paul Claudon, Michel Laguerre, Sabine Castano, Bernard Desbat, Dominqiue Cavagnat, Eric Ennifar, Brice Kauffmann and Gilles Guichard
J. Am. Chem. Soc. 2013, 135, 4884-92.



ysteine-rich domain one of CD40 mediates receptor self-assembly
Cristian R. Smulski, Julien Beyrath, Marion Decossas, Neila Chekkat, Philippe Wolff, Karine Estieu-Gionnet, Gilles Guichard, Daniel Speiser, Pascal Schneider, Sylvie Fournel
J. Biol. Chem. 2013 288, 10914-22.



Controlling Helix Formation in the γ-Peptide Superfamily : Heterogeneous Foldamers with Urea/Amide and Urea/Carbamate Backbones
Nagendar Pendem, Yella Reddy Nelli, Céline Douat, Lucile Fischer, Michel Laguerre, Eric Ennifar, Brice Kauffmann, Gilles Guichard
Angew. Chem. Int Ed. 2013, 52, 4147-51.



Sequencing of Oligourea Foldamers by Tandem Mass Spectrometry
Katell Bathany, Neil W. Owens, Gilles Guichard, Jean-Marie Schmitter.
J. Am. Soc. Mass. Spectrom. 2013, 24, 458-62.



Multimerization of an apoptogenic TRAIL-mimicking peptide by using adamantane-based dendrons
Lamanna, G.; Smulski, C. R.; Chekkat, N.; Estieu-Gionnet, K.;  Guichard, G.; Fournel, S.; Bianco, A.
Chem. Eur. J. 2013, 19, 1762–1768.



Derivatisation of preformed platinum N-heterocyclic carbene complexes with amino acid and peptide ligands, and cytotoxic activities towards human cancer cells
Chardon, E.; Dahm, G.; Guichard, G.; Bellemin-Laponnaz, S.
Organometallics 2012, 31, 7618−7621.



Easy Derivatisation of Group 10 N-Heterocyclic Carbene Complexes and In Vitro Evaluation of an Anticancer Oestradiol Conjugate
Chardon, E.; Puleo, G. L.; Dahm, G.; Fournel, S.; Guichard, G.; Bellemin-Laponnaz, S.
ChemPlusChem, 2012, 77, 1028-1038.



Development of a practical solid-phase synthesis approach to 1,3,5-triazepan-2,6-diones.
Boeglin J, Venin C, Guichard G.
Tetrahedron, 2012, 68, 7472-7478.



Microwave-enhanced solid phase synthesis of N,N’-linked aliphatic oligoureas and related hybrids
Douat-Casassus C, Pulka K, Claudon P, Guichard G
Org. Lett. 2012, 14, 3130–3133.



An activated building block for the introduction of the histidine side-chain in aliphatic oligourea foldamers.
Nelli YR, Douat-Casassus C, Claudon P, Kauffmann B, Didierjean C,Guichard G.
Tetrahedron 2012, 68, 4492-4500 (Special issue on Chemistry of Foldamers, edited by G. Guichard & I. Huc).



Solid State NMR studies of oligourea foldamers: Interaction of 15N-labelled amphiphilic helices with oriented lipid membranes.
Aisenbrey C, Nagendar P, Guichard G, Bechinger B.
Org Biomol Chem 2012, 10, 1440-1447.



Condensation Approach to Aliphatic Oligourea Foldamers: Helices with N-(Pyrrolidin-2-ylmethyl)ureido Junctions.
Fremaux J, Fischer L, Arbogast T, Kauffmann B, Guichard G.
Angew Chem Int Ed Engl 2011 50, 11382-5.



Stabilized helical peptides: overview of the technologies and therapeutic promises. (review)
Estieu-Gionnet K, Guichard G.
Expert Opin Drug Discov 2011 6, 937-63.



Structure-Based Design of Short Peptide Ligands Binding onto the E. coli Processivity Ring.
Wolff P, Oliéric V, Briand JP, Chaloin O, Dejaegere A, Dumas P, Ennifar E, Guichard G, Wagner J., Burnouf DY.
J Med Chem 2011 54, 4627-37.



Synthetic foldamers.
Guichard G, Huc I.
Chem Commun (Camb) 2011 47, 5933-41.



Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement.
Chardon E, Puleo GL, Dahm G, Guichard G, Bellemin-Laponnaz S.
Chem Commun (Camb) 2011 47, 5864-6.



Experimental and Theoretical Study of the Vibrational Spectra of Oligoureas: Helical versus beta-Sheet-Type Secondary Structures.
Cavagnat D, Claudon P, Fischer L, Guichard G, Desbat B.
J Phys Chem B 2011 115, 4446-52.



Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.
Gorska K, Beyrath J, Fournel S, Guichard G, Winssinger N.
Chem Commun (Camb) 2010 46, 7742-4.



5-(3,4-Dimethoxybenzyl)-7-isopropyl-1,3,5-triazepane-2,6-dione acetonitrile solvate refined using a multipolar atom model.
Ejsmont K, Boeglin J, Didierjean C, Guichard G, Jelsch C.
Acta Crystallogr C 2010 66, o292-4.



Folding and self-assembly of aromatic and aliphatic urea oligomers: Towards connecting structure and function. (Perspective)
Fischer L, Guichard G.
Org Biomol Chem 2010 8, 3101-17.



Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity.
Pavet V, Beyrath J, Pardin C, Morizot A, Lechner MC, Briand JP, Wendland M, Maison W, Fournel S, Micheau O, Guichard G, Gronemeyer H.
Cancer Res 2010 70, 1101-10.



The Canonical Helix of Urea Oligomers at Atomic Resolution. Insight Into Folding-induced Axial Organization.
Fischer L, Claudon P, Pendem N, Miclet E, Didierjean C, Ennifar E, Guichard G.
Angew Chem Int Ed Engl 2010 49, 1067-70.



Consequences of Isostructural Main-Chain Modifications for the Design of Antimicrobial Foldamers: Helical Mimics of Host-Defense Peptides Based on a Heterogeneous Amide/Urea Backbone.
Claudon P, Violette A, Lamour K, Decossas M, Fournel S, Heurtault B, Godet J, Mély Y, Jamart-Grégoire B, Averlant-Petit M-C, Briand J-P, Duportail G, Monteil H, Guichard G.
Angew Chem Int Ed Engl 2010 49, 333-36.



Anion-Macrodipole Interactions: Self-Assembling Oligourea/Amide Macrocycles as Anion Transporters that Respond to Membrane Polarization.
Hennig A, Fischer L, Guichard G, Matile S.
J Am Chem Soc 2009 131, 16889-95.



Aza-beta3-cyclopeptides: A New Way of Controlling Nitrogen Chirality.
Mocquet C, Salaün A, Claudon P, Grel BL, Potel M, Guichard G, Jamart-Grégoire B, Le Grel P.
J Am Chem Soc 2009 131, 14521-25.



Control of duplex formation and columnar self-assembly with heterogeneous amide/urea macrocycles.
Fischer L, Decossas M, Briand JP, Didierjean C, Guichard G.
Angew Chem Int Ed Engl 2009 48, 1625-8.



Solution structure determination of oligoureas using methylene spin state selective NMR at 13C natural abundance.
Guichard G, Violette A, Chassaing G, Miclet E.
Magn Reson Chem 2008 46, 918-24.



tert-Butyl 3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate.
Lechner M-C, Aubert E, Guichard G, Didierjean C.
Acta Cryst Section E 2008 64, o2039.



Synthetic methods for the preparation of triazepandiones and review of their applications. Lena G, Guichard G.
Current Org Chem 2008 12, 813-35.



Suppression of tumor growth and angiogenesis by a specific antagonist of the cell-surface expressed nucleolin.
Destouches D, El Khoury D, Hamma-Kourbali Y, Krust B, Albanese P, Katsoris P, Guichard G, Briand JP, Courty J, Hovanessian AG.
PLoS ONE 2008 3, e2518.



Propensity for local folding induced by the urea fragment in short-chain oligomers.
Fischer L, Didierjean C, Jolibois F, Semetey V, Lozano JM, Briand JP, Marraud M, Poteau R, Guichard G.
Org Biomol Chem 2008 6, 2596-610.



Exploring helical folding of oligoureas during chain elongation by high-resolution magic-angle-spinning (HRMAS) NMR spectroscopy.

Violette A, Lancelot N, Poschalko A, Piotto M, Briand JP, Raya J, Elbayed K, Bianco A, Guichard G.
Chem Eur J 2008 14, 3874-82.



Synthesis of enantiopure di(tert-butyl) (2S,4S)-4-hydroxy-6-oxo-1,2,-piperidinedicarboxylate.

Chaloin O., Cabart F., Marin J., Zhang H., Guichard G.

Org. Synth. 2008, 85, 147-157.



Synthesis of a Galactosylated 4-Hydroxylysine Building Block and Its Incorporation into a Collagen Immunodominant Glycopeptide.
Marin J, Briand J-P, Guichard G.
Eur. J.Org. Chem. 2008, 1005-12.



Foldamers Based on Remote Intrastrand Interactions.
Le Grel, P.; Guichard, G.
In Foldamers: Structure, Properties, and Applications, Hecht, S.; Huc, I., Eds. Wiley-VCH: Weinheim, 2007; pp 35-74.



Small multivalent architectures mimicking homotrimers of the TNF superfamily member CD40L: delineating the relationship between structure and effector function.
Trouche N, Wieckowski S, Sun W, Chaloin O, Hoebeke J, Fournel S, Guichard G.
J Am Chem Soc 2007 129, 13480-92.



Insights into spatial configuration of a galactosylated epitope required to trigger arthritogenic T-cell receptors specific for the sugar moiety.
Glatigny S, Blaton MA, Marin J, Mistou S, Briand JP, Guichard G, Fournier C, Chiocchia G. Arthritis Res Ther 2007 9, R92.



Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection.
Habib M, Noval Rivas M, Chamekh M, Wieckowski S, Sun W, Bianco A, Trouche N, Chaloin O, Dumortier H, Goldman M, Guichard G, Fournel S, Vray B.
J Immunol 2007 178, 6700-4.



7-Isopropyl-5-methyl-1,3,5-triazepan-2,6-dione deuterated chloroform 0.94-solvate.
Aubert E, Lena G, Gellenoncourt M, Durain E, Guichard G, Didierjean C.
Acta Cryst. Section E 2007 63, o2306-o08.



Succinimidyl Carbamate Derivatives from N-Protected alpha-Amino Acids and Dipeptides-Synthesis of Ureidopeptides and Oligourea/Peptide Hybrids.
Fischer L, Semetey V, Lozano J-M, Schaffner A-P, Briand J-P, Didierjean C, Guichard G.
Eur. J. of Org. Chem. 2007, 2511-25.



Calculations on the Electronic Excited States of Ureas and Oligoureas.
Oakley MT, Guichard G, Hirst JD.
J Phys Chem B 2007 111, 3274-79.



In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.
Muller P, Lena G, Boilard E, Bezzine S, Lambeau G, Guichard G, Rognan D.
J Med Chem 2006 49, 6768-78. link



Porous 3-D honeycomb architecture by self-assembly of helical H-bonded molecular tapes.
Schaffner A-P, Lena G, Roussel S, Wawrezinieck A, Aubry A, Briand J-P, Didierjean C, Guichard G.
Chem Commun 2006, 4069-71.



1,3,5-Triazepan-2,6-diones as Structurally Diverse and Conformationally Constrained Dipeptide Mimetics: Identification of Malaria Liver Stage Inhibitors from a Small Pilot Library.
Lena G, Lallemand E, Gruner A-C, Boeglin J, Roussel S, Schaffner A-P, Aubry A, Franetich J-F, Mazier D, Landau I, Briand J-P, Didierjean C, Rénia L, Guichard G.
Chem Eur J 2006 12, 8498-512.



Mimicking Helical Antibacterial Peptides with Nonpeptidic Folding Oligomers.
Violette A, Fournel S, Lamour K, Chaloin O, Frisch B, Briand J-P, Monteil H, Guichard G.
Chem Biol 2006 13, 531-38.



Solid-phase synthesis of CD40L mimetics.
Bianco A, Fournel S, Wieckowski S, Hoebeke J, Guichard G.
Org Biomol Chem 2006 4, 1461-3.



Lena G, Wenger E, Guichard G, Didierjean C.
Acta Cryst. Section E 2006 62, o518-o20.



N,N’-Linked Oligoureas as Foldamers: Chain Length Requirements for Helix Formation in Protic Solvent Investigated by Circular Dichroism, NMR Spectroscopy, and Molecular Dynamics.
Violette A, Averlant-Petit MC, Semetey V, Hemmerlin C, Casimir R, Graff R, Marraud M, Briand J-P, Rognan D, Guichard G.
J Am Chem Soc 2005 127, 2156-64.