Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes.

Chekkat N, Lombardo CM, Seguin C, Lechner MC, Dufour F, Nominé Y, De Giorgi M, Frisch B, Micheau O, Guichard G, Altschuh D, Fournel S.

Oncotarget. 2018, 9 (21), 15566-15578. link


Postelongation Strategy for the Introduction of Guanidinium Units in the Main Chain of Helical Oligourea Foldamers.

K. Pulka-Ziach, S. Antunes, C. Perdriau, B. Kauffmann, M. Pasco, C. Douat, G. Guichard.

J. Org. Chem. 2018, 83 (5), 2530-2541. linkjo-2017-018953_0010


Synthesis and structural characterization of alkyne-functionalized N-heterocyclic carbene complexes of ruthenium, palladium and rhodium.

E. Chardon, G. Dahm, G. Guichard, S. Bellemin-Laponnaz

Inorg. Chim. Acta 2017, 467 (Supplement C), 33-38. link



Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C-C Bond-Forming Reactions.

Bécart D, Diemer V, Salaün A, Oiarbide M, Nelli YR, Kauffmann B, Fischer L, Palomo C, Guichard G.

J. Am. Chem. Soc. 2017, 139 (36), 12524-12532. link



Foldamers in Medicinal Chemistry.

M. Pasco, C. Dolain, G. Guichard, in  Comprehensive Supramolecular Chemistry II, ed Atwood JL (Elsevier, Oxford), Vol 5, pp 89–125.



Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers.

Antunes S, Corre JP, Mikaty G, Douat C, Goossens PL, Guichard G.

Bioorg Med Chem. 2017, 25(16), 4245-4252. link



Proline-rich antimicrobial peptides targeting protein synthesis.

Nat. Prod. Rep. 2017, doi: 10.1039/c7np00020k. link



Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions.

Gavin W. Collie, Remy Bailly, Karolina Pulka-Ziach, Caterina M. Lombardo, Laura Mauran, Nada Taib-Maamar, Jean Dessolin, Cameron D. Mackereth, and Gilles Guichard.

J. Am. Chem. Soc. 2017, 139, 6128–6137. link



N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Florent Dufour, Thibault Rattier, Sarah Shirley, Gaelle Picarda, Andrei Alexandru Constantinescu, Aymeric Morlé, Al Batoul Zakaria, Guillaume Marcion, Sebastien Causse, Eva Szegezdi, Dirk Michael Zajonc, Renaud Seigneuric, Gilles Guichard, Tijani Gharbi, Fabien Picaud, Guillaume Herlem, Carmen Garrido, Pascal Schneider, Chris Alan Benedict, and Olivier Micheau.

Cell Death Differ. 2017, 24, 500–510. link


Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.

Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel.

Cell Death and Disease 2017, 8, e2601; doi:10.1038/cddis.2017.22 link